While the Second Continental Congress met in the early summer of 1776, colonists in the far away backcountry of South Carolina faced a threat from a perennial foe, the Cherokees. While delegates debated a declaration of independence, war parties struck settlements between the Broad and Saluda Rivers in the Ninety Six District. In response to these raids, militia Major Andrew Williamson mustered his Ninety Six regiment. Augmented by militia from the Carolinas and Virginia, he commenced a campaign against the Cherokee villages along the eastern face of the Blue Ridge.

Williamson struck at Esseneca on August 1. The colonials sustained twenty casualties but forced the warriors to abandon the village. Over the course of the next week, Williamson moved further into enemy territory. Rather than engage his force, the Cherokees retreated before the advance. Williamson burned a number of towns including Oconee, Estatoe and Toxaway.

The regiment reached Tamassee on August 12. Once again, Williamson found the village abandoned. He decided to send out scouting parties to examine the nearby hills. One of the patrols was led by a company commander from the Long Canes region of South Carolina, Captain Andrew Pickens. He took with him about sixty men. To cover more ground, Pickens divided his group and continued on with thirty five militiamen.